产品名称
VPS13A Rabbit Polyclonal Antibody
基因名称
VPS13A CHAC KIAA0986
蛋白名称
Vacuolar protein sorting-associated protein 13A (Chorea-acanthocytosis protein) (Chorein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23230
Human Swissprot No.
Q96RL7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96RL7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=271564
Mouse Swissprot No.
Q5H8C4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5H8C4/entry
特异性
This antibody detects endogenous levels of VPS13A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in red blood cells (at protein level) (PubMed:31086825). Widely expressed, with high expression in brain, heart, skeletal muscle and kidney (PubMed:15498460).
细胞定位
Mitochondrion outer membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Lipid droplet . Golgi apparatus . Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle . Localizes at mitochondria-endosomes and mitochondria-endoplasmic reticulum contact sites (PubMed:30741634, PubMed:30709847, PubMed:30093493). .
功能
Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids . Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria . Negatively regulates lipid droplet size and motility . Required for efficient lysosomal protein degradation .
