产品名称
TTBK1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84630
Human Swissprot No.
Q5TCY1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5TCY1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/106763
Mouse Swissprot No.
Q6PCN3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PCN3
免疫原
Synthesized peptide derived from human TTBK1 AA range: 429-479
特异性
This antibody detects endogenous levels of TTBK1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Summary:This gene belongs to the casein kinase 1 superfamily. The encoded protein is a neuron-specific, serine/threonine and tyrosine kinase, which regulates phosphorylation of tau, a protein that associates with microtubule assemblies and stabilizes them. Genetic variants in this gene are associated with Alzheimer's disease. [provided by RefSeq, Jul 2016],
组织表达
Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:It is uncertain whether Met-1 or Met-14 is the initiator.,cofactor:Divalent cations. Magnesium or, to a lesser extent, manganese, but not calcium or zinc.,function:Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
