产品名称
SLC7A6 Rabbit Polyclonal Antibody
蛋白名称
Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9057
Human Swissprot No.
Q92536
Human Swissprot Link
https://www.uniprot.org/uniprot/Q92536
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=330836
Mouse Swissprot No.
Q8BGK6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BGK6/entry
特异性
This antibody detects endogenous levels of SLC7A6 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines.
细胞定位
Basolateral cell membrane ; Multi-pass membrane protein .
功能
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
