产品名称
RDH12 Rabbit Polyclonal Antibody
蛋白名称
Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=145226
Human Swissprot No.
Q96NR8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96NR8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=77974
Mouse Swissprot No.
Q8BYK4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BYK4/entry
特异性
This antibody detects endogenous levels of RDH12 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed, mostly in retina, kidney, brain, skeletal muscle, pancreas and stomach.
细胞定位
Endoplasmic reticulum membrane .
功能
Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol . Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal . May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation . Has no dehydrogenase activity towards steroids .
