产品名称
SC6A3 Rabbit Polyclonal Antibody
蛋白名称
Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q01959
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q01959/entry
Mouse Swissprot No.
Q61327
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61327
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P23977
免疫原
Synthesized peptide derived from part region of human protein
特异性
SC6A3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009],
组织表达
Highly expressed in substantia nigra (PubMed:7637582). Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level) (PubMed:17296554). Expressed in the striatum (at protein level) (PubMed:17296554).
细胞定位
Cell membrane ; Multi-pass membrane protein . Cell projection, neuron projection . Cell projection, axon . Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity). .
信号通路
Parkinson's disease;
功能
function:Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.,miscellaneous:This protein is the target of psychomotor stimulants such as amphetamines or cocaine.,online information:Dopamine transporter entry,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subunit:Homooligomer; disulfide-linked. Interacts with PRKCABP and TGFB1I1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
