产品名称
KIF13A Rabbit Polyclonal Antibody
蛋白名称
Kinesin-like protein KIF13A (Kinesin-like protein RBKIN)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63971
Human Swissprot No.
Q9H1H9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H1H9
Mouse Swissprot No.
Q9EQW7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EQW7/entry
特异性
This antibody detects endogenous levels of KIF13A at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed, with highest levels in heart, brain and skeletal muscle.
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane . Recruited to the midbody during cytokinesis.
功能
Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.
