产品名称
CERK Rabbit Polyclonal Antibody
蛋白名称
Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64781
Human Swissprot No.
Q8TCT0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8TCT0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=223753
Mouse Swissprot No.
Q8K4Q7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K4Q7/entry
特异性
This antibody detects endogenous levels of CERK at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein .
功能
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate . Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines . Shows a greater preference for D-erythro isomer of ceramides . Binds phosphoinositides .
