产品名称
C7orf43 Rabbit Polyclonal Antibody
蛋白名称
Uncharacterized protein C7orf43
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55262
Human Swissprot No.
Q8WVR3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8WVR3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=231807
Mouse Swissprot No.
Q3UTZ3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UTZ3/entry
特异性
This antibody detects endogenous levels of C7orf43 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Broadly expressed. High levels in brain, cerebellum, testis and whole blood.
细胞定位
Cytoplasm, cytoskeleton, spindle . Vesicle . Midbody . Cytoplasm . During mitosis, precedes alpha-tubulin in gap formation of cell abscission at the midbody and is co-localized with PLK1 at the edges of microtubules extensions of daughter cells post cytokinesis abscission (PubMed:30715179). Colocalizes with RAB3IP on preciliary vesicles (PubMed:31467083). .
功能
Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether . TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis . Modulates YAP1 activity as transcriptional regulator .
