产品名称
RMND5B Rabbit Polyclonal Antibody
基因名称
RMND5B UNQ2508/PRO5996
蛋白名称
Protein RMD5 homolog B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64777
Human Swissprot No.
Q96G75
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96G75
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66089
Mouse Swissprot No.
Q91YQ7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91YQ7/entry
特异性
This antibody detects endogenous levels of RMND5B at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, cytosol .
功能
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex . Catalytic activity of the complex is required for normal cell proliferation . The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 .
