产品名称
PACSIN3 Rabbit Polyclonal Antibody
蛋白名称
Protein kinase C and casein kinase substrate in neurons protein 3 (Endophilin I) (SH3 domain-containing protein 6511)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29763
Human Swissprot No.
Q9UKS6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UKS6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80708
Mouse Swissprot No.
Q99JB8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99JB8/entry
特异性
This antibody detects endogenous levels of PACSIN3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney.
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Detected at the inner aspect of the plasma membrane in myotubes. .
功能
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).
