产品名称
MAPKBP1 Rabbit Polyclonal Antibody
基因名称
MAPKBP1 JNKBP1 KIAA0596
蛋白名称
Mitogen-activated protein kinase-binding protein 1 (JNK-binding protein 1) (JNKBP-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23005
Human Swissprot No.
O60336
Human Swissprot Link
https://www.uniprot.org/uniprot/O60336
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26390
Mouse Swissprot No.
Q6NS57
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6NS57/entry
特异性
This antibody detects endogenous levels of MAPKBP1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in intestinal mucosa, where it is detected in epithelial cells, endothelial cells, smooth muscle cells and immune cells, such as lymphocytes (PubMed:22700971). Expressed in kidney (PubMed:28089251).
细胞定位
Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle pole . Not detected in the cilium. Localized around the poles of the mitotic spindle from prophase to anaphase in mitotic cells. .
功能
Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response . Involved in JNK signaling pathway (By similarity).
