产品名称
KTELC1 Rabbit Polyclonal Antibody
基因名称
POGLUT1 C3orf9 CLP46 KTELC1 MDSRP MDS010 UNQ490/PRO1006
蛋白名称
Protein O-glucosyltransferase 1 (EC 2.4.1.-) (CAP10-like 46 kDa protein) (hCLP46) (KTEL motif-containing protein 1) (Myelodysplastic syndromes relative protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56983
Human Swissprot No.
Q8NBL1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NBL1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=224143
Mouse Swissprot No.
Q8BYB9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BYB9/entry
特异性
This antibody detects endogenous levels of KTELC1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. Expressed in the epidermis, especially in the upper parts, stratum spinosum and stratum granulosum (at protein level).
细胞定位
Endoplasmic reticulum lumen .
功能
Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C . Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 . Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development . Notch glucosylation does not affect Notch ligand binding . Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity).
