产品名称
REXO2 Rabbit Polyclonal Antibody
基因名称
REXO2 SFN SMFN CGI-114
蛋白名称
Oligoribonuclease, mitochondrial (EC 3.1.-.-) (RNA exonuclease 2 homolog) (Small fragment nuclease)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25996
Human Swissprot No.
Q9Y3B8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y3B8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=104444
Mouse Swissprot No.
Q9D8S4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D8S4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=300689
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U1X1/entry
特异性
This antibody detects endogenous levels of REXO2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus.
细胞定位
Mitochondrion intermembrane space . Mitochondrion matrix . Mitochondrion . Cytoplasm . Nucleus .; [Isoform 3]: Cytoplasm . Nucleus .
功能
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides . Binds and degrades longer oligonucleotides with a lower affinity . Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing . Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome . Essential for embryonic development (By similarity). ; [Isoform 3]: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides.
