产品名称
SL9C1 Rabbit Polyclonal Antibody
蛋白名称
Sodium/hydrogen exchanger 10 (Na(+)/H(+) exchanger 10) (NHE-10) (Solute carrier family 9 member 10) (Solute carrier family 9 member C1) (Sperm-specific Na(+)/H(+) exchanger) (sNHE)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q4G0N8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q4G0N8/entry
Mouse Swissprot No.
Q6UJY2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6UJY2
免疫原
Synthesized peptide derived from part region of human protein
特异性
SL9C1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family (see SLC9A1, MIM 107310) and is required for male fertility and sperm motility (Wang et al., 2003 [PubMed 14634667]).[supplied by OMIM, Apr 2009],
细胞定位
Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein .
功能
domain:The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown.,function:Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC).,similarity:Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:Interacts with soluble adenylyl cyclase (sAC).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
