产品名称
NHLRC1 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase NHLRC1 (EC 6.3.2.-) (Malin) (NHL repeat-containing protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=378884
Human Swissprot No.
Q6VVB1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6VVB1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=105193
Mouse Swissprot No.
Q8BR37
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BR37/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=364682
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6IMG5/entry
特异性
This antibody detects endogenous levels of NHLRC1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas.
细胞定位
Endoplasmic reticulum. Nucleus. Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus.
功能
E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.
