产品名称
NAC3 Rabbit Polyclonal Antibody
蛋白名称
Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P57103
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P57103/entry
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P70549
免疫原
Synthesized peptide derived from human protein . at AA range: 530-610
特异性
NAC3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013],
组织表达
Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.
细胞定位
Cell membrane ; Multi-pass membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, dendritic spine . Cell membrane, sarcolemma . Cytoplasm, sarcoplasm . Cell junction . Mitochondrion outer membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Detected at neuromuscular junctions. .
功能
enzyme regulation:By intracellular calcium ions.,function:Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.,similarity:Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.,similarity:Contains 2 Calx-beta domains.,tissue specificity:Isoform 2 is expressed in brain and skeletal muscle; Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle; Isoform 4 is expressed in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
