产品名称
CHTF18 Rabbit Polyclonal Antibody
基因名称
CHTF18 C16orf41 CTF18
蛋白名称
Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63922
Human Swissprot No.
Q8WVB6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8WVB6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=214901
Mouse Swissprot No.
Q8BIW9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BIW9/entry
特异性
This antibody detects endogenous levels of CHTF18 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Associates with chromatin during S phase.
功能
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage .
