产品名称
PNLIPRP2 Rabbit Polyclonal Antibody
蛋白名称
Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5408
Human Swissprot No.
P54317
Human Swissprot Link
https://www.uniprot.org/uniprot/P54317
Mouse Swissprot No.
P17892
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P17892/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117554
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P54318/entry
特异性
This antibody detects endogenous levels of PNLIPRP2 at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Secreted . Zymogen granule membrane ; Peripheral membrane protein . Cell projection, neuron projection . Localizes to neurite tips in neuronal cells. .
功能
Lipase that primarily hydrolyzes triglycerides and galactosylglycerides . In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides . Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity . Can completely deacylate triacylglycerols . When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids . Hydrolyzes medium- and long-chain fatty acyls in galactolipids . May act together with LIPF to hydrolyze partially digested triglycerides . Hydrolyzes long-chain monoglycerides with high efficiency . In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity . In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
