产品名称
SLFN11 Rabbit Polyclonal Antibody
蛋白名称
Schlafen family member 11
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=91607
Human Swissprot No.
Q7Z7L1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q7Z7L1
特异性
This antibody detects endogenous levels of SLFN11 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.
细胞定位
Nucleus . Chromosome . Recruited to stressed replication forks carrying extended RPA filaments (PubMed:29395061). Recruited to DNA damage sites via interaction with RPA1 (PubMed:26658330, PubMed:29395061). .
功能
Inhibitor of DNA replication that promotes cell death in response to DNA damage . Acts as a guardian of the genome by killing cells with defective replication . Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death . Acts independently of ATR . Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis . Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner . Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides . The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation . Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA .
