产品名称
GGA1 Rabbit Polyclonal Antibody
蛋白名称
ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26088
Human Swissprot No.
Q9UJY5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UJY5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=106039
Mouse Swissprot No.
Q8R0H9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R0H9/entry
特异性
This antibody detects endogenous levels of GGA1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed.
细胞定位
Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein. Endosome membrane ; Peripheral membrane protein. Early endosome membrane ; Peripheral membrane protein .
功能
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif . Mediates export of the GPCR receptor ADRA2B to the cell surface . Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network .
