产品名称
OVCA1 Rabbit Polyclonal Antibody
基因名称
DPH1 DPH2L DPH2L1 OVCA1
蛋白名称
Diphthamide biosynthesis protein 1 (DPH1 homolog) (HsDph1) (Diphthamide biosynthesis protein 2 homolog-like 1) (DPH-like 1) (DPH2-like 1) (Diphthamide biosynthesis protein 2-like) (Ovarian cancer-associated gene 1 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1801
Human Swissprot No.
Q9BZG8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BZG8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116905
Mouse Swissprot No.
Q5NCQ5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5NCQ5/entry
特异性
This antibody detects endogenous levels of OVCA1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors.
细胞定位
Nucleus . Cytoplasm . Punctate, primarily perinuclear localization.
功能
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity).
