产品名称
ABCA2 Rabbit Polyclonal Antibody
蛋白名称
ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20
Human Swissprot No.
Q9BZC7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BZC7
Mouse Swissprot No.
P41234
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P41234/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79248
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ESR9/entry
特异性
This antibody detects endogenous levels of ABCA2 at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
[Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver. ; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes.
细胞定位
Endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Forms discrete, punctate intracellular vesicles. .
功能
Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes . In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP . May play a role in myelin formation (By similarity).
