产品名称
SCNAA Rabbit Polyclonal Antibody
蛋白名称
Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y5Y9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y5Y9/entry
Mouse Swissprot No.
Q6QIY3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6QIY3
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q62968
免疫原
Synthesized peptide derived from part region of human protein
特异性
SCNAA Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],
组织表达
Expressed in the dorsal root ganglia and sciatic nerve.
细胞定位
Cell membrane ; Multi-pass membrane protein . It can be translocated to the cell membrane through association with S100A10. .
功能
domain:The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.,function:This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms.,PTM:Ubiquitinated by NEDD4L; which promotes its endocytosis.,similarity:Belongs to the sodium channel family.,similarity:Contains 1 IQ domain.,subcellular location:It can be translocated to the extracellular membrane through association with S100A10.,subunit:The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, TCTEL1 and PDZD2. Interacts with proteins such as FSTL1, PRX, TCTEL1, PDZD2, S100A10 and many others (By similarity). Interacts with NEDD4 and NEDD4L.,tissue specificity:Expressed in the dorsal root ganglia and sciatic nerve.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
