产品名称
MEMO1 Rabbit Polyclonal Antibody
基因名称
MEMO1 C2orf4 MEMO NS5ATP7 CGI-27
蛋白名称
Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51072
Human Swissprot No.
Q9Y316
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y316
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76890
Mouse Swissprot No.
Q91VH6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91VH6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=298787
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4QQR9/entry
特异性
This antibody detects endogenous levels of MEMO1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
