产品名称
TRAM2 Rabbit Polyclonal Antibody
蛋白名称
Translocating chain-associated membrane protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9697
Human Swissprot No.
Q15035
Human Swissprot Link
https://www.uniprot.org/uniprot/Q15035
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170829
Mouse Swissprot No.
Q924Z5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q924Z5/entry
特异性
This antibody detects endogenous levels of TRAM2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Membrane ; Multi-pass membrane protein .
功能
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) .
