产品名称
Toca 1 Rabbit Polyclonal Antibody
基因名称
FNBP1L C1orf39 TOCA1
蛋白名称
Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54874
Human Swissprot No.
Q5T0N5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5T0N5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=214459
Mouse Swissprot No.
Q8K012
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K012/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=310839
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q2HWF0/entry
特异性
This antibody detects endogenous levels of Toca 1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Cytoplasmic vesicle . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
功能
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.
