产品名称
TMEM35 Rabbit Polyclonal Antibody
蛋白名称
Transmembrane protein 35
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59353
Human Swissprot No.
Q53FP2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q53FP2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67564
Mouse Swissprot No.
Q9D328
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D328/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=308134
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6JAM9/entry
特异性
This antibody detects endogenous levels of TMEM35 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Peroxisome membrane ; Multi-pass membrane protein . Cytoplasmic vesicle . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Shedding may lead to a soluble peptide. .
功能
Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain . Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors . Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly . Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form .
