产品名称
TBRG1 Rabbit Polyclonal Antibody
蛋白名称
Transforming growth factor beta regulator 1 (Nuclear interactor of ARF and Mdm2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84897
Human Swissprot No.
Q3YBR2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q3YBR2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21376
Mouse Swissprot No.
Q3UB74
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UB74/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=300521
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5PQK8/entry
特异性
This antibody detects endogenous levels of TBRG1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma.
功能
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.
