产品名称
CASQ1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/844
Human Swissprot No.
P31415
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P31415/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12372
Mouse Swissprot No.
O09165
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O09165
Rat Gene Link
https://www.uniprot.org/uniprot/686019
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P19633
免疫原
Synthesized peptide derived from human CASQ1 AA range: 322-372
特异性
This antibody detects endogenous levels of CASQ1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the skeletal muscle specific member of the calsequestrin protein family. Calsequestrin functions as a luminal sarcoplasmic reticulum calcium sensor in both cardiac and skeletal muscle cells. This protein, also known as calmitine, functions as a calcium regulator in the mitochondria of skeletal muscle. This protein is absent in patients with Duchenne and Becker types of muscular dystrophy. [provided by RefSeq, Jun 2013],
组织表达
Expressed in myoblasts (at protein level).
细胞定位
Endoplasmic reticulum . Sarcoplasmic reticulum . Sarcoplasmic reticulum lumen . Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side . Mitochondrion matrix . This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells (PubMed:28895244). In a minority of cells, homogeneously detected in the ER lumen (PubMed:28895244). Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium (PubMed:27185316). .
功能
function:Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction.,function:Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium. Also binds laminin.,online information:Calsequestrin entry,similarity:Belongs to the calsequestrin family.,subcellular location:This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Also mitochondrial according to PubMed:7945294.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
