产品名称
SPO11 Rabbit Polyclonal Antibody
蛋白名称
Meiotic recombination protein SPO11 (Cancer/testis antigen 35) (CT35)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23626
Human Swissprot No.
Q9Y5K1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y5K1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26972
Mouse Swissprot No.
Q9WTK8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTK8/entry
特异性
This antibody detects endogenous levels of SPO11 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in testis.
功能
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
