产品名称
SMG8 Rabbit Polyclonal Antibody
蛋白名称
Protein SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55181
Human Swissprot No.
Q8ND04
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8ND04
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74133
Mouse Swissprot No.
Q8VE18
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VE18/entry
特异性
This antibody detects endogenous levels of SMG8 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.
