产品名称
PHF21A Rabbit Polyclonal Antibody
基因名称
PHF21A BHC80 KIAA1696 BM-006
蛋白名称
PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51317
Human Swissprot No.
Q96BD5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96BD5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=192285
Mouse Swissprot No.
Q6ZPK0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZPK0/entry
特异性
This antibody detects endogenous levels of PHF21A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in brain (PubMed:31649809). Expressed at lower level in other tissues, including heart, kidney, liver, lung and skeletal muscle (PubMed:31649809). Abundantly expressed in fetal brain (PubMed:31649809).
功能
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
