产品名称
PDZD8 Rabbit Polyclonal Antibody
蛋白名称
PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=118987
Human Swissprot No.
Q8NEN9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NEN9
特异性
This antibody detects endogenous levels of PDZD8 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein . Localizes at mitochondria-endoplasmic reticulum contact sites. .
功能
Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes . PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer . In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons . Plays an indirect role in the regulation of cell morphology and cytoskeletal organization . May inhibit herpes simplex virus 1 infection at an early stage .
