BD-PN7993

MCTS1 Rabbit Polyclonal Antibody

常规抗体

MCTS1 MCT1

Malignant T-cell-amplified sequence 1 (MCT-1) (Multiple copies T-cell malignancies)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

28985

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=28985

Q9ULC4

https://www.uniprot.org/uniprot/Q9ULC4

68995

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68995

Q9DB27

https://www.uniprot.org/uniprotkb/Q9DB27/entry

302500

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=302500

Q4G009

https://www.uniprot.org/uniprotkb/Q4G009/entry

This antibody detects endogenous levels of MCTS1 at Human, Mouse,Rat

WB 1:500-2000

20kD

-15°C to -25°C/1 year(Do not lower than -25°C)

Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.

Cytoplasm . Nuclear relocalization after DNA damage.

Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

现货