产品名称
CCL25 Rabbit Polyclonal Antibody
蛋白名称
C-C motif chemokine 25 (Chemokine TECK) (Small-inducible cytokine A25) (Thymus-expressed chemokine)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O15444
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15444/entry
Mouse Swissprot No.
O35903
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35903
免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
CCL25 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014],
组织表达
Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.
信号通路
Cytokine-cytokine receptor interaction;Chemokine;Intestinal immune network for IgA production;
功能
function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1.,online information:CCL25 entry,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
