产品名称
KIRREL3 Rabbit Polyclonal Antibody
基因名称
KIRREL3 KIAA1867 NEPH2 UNQ5923/PRO4502/PRO19814
蛋白名称
Kin of IRRE-like protein 3 (Kin of irregular chiasm-like protein 3) (Nephrin-like protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84623
Human Swissprot No.
Q8IZU9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8IZU9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67703
Mouse Swissprot No.
Q8BR86
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BR86/entry
特异性
This antibody detects endogenous levels of KIRREL3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in fetal and adult brain (PubMed:19012874). Also expressed in kidney, specifically in podocytes of kidney glomeruli (PubMed:12424224). Also expressed in skeletal muscle (PubMed:25488023).
细胞定位
Cell membrane ; Single-pass type I membrane protein .; [Processed kin of IRRE-like protein 3]: Secreted .
功能
Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.
