产品名称
FATE1 Rabbit Polyclonal Antibody
蛋白名称
Fetal and adult testis-expressed transcript protein (Cancer/testis antigen 43) (CT43) (Tumor antigen BJ-HCC-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89885
Human Swissprot No.
Q969F0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q969F0
Mouse Swissprot No.
Q8CEK7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CEK7/entry
特异性
This antibody detects endogenous levels of FATE1 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919).
细胞定位
Mitochondrion . Mitochondrion outer membrane . Endoplasmic reticulum membrane ; Single-pass membrane protein ; Cytoplasmic side . Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER. .
功能
Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis . May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling .
