产品名称
DHDDS Rabbit Polyclonal Antibody
蛋白名称
Dehydrodolichyl diphosphate synthase (Dedol-PP synthase) (EC 2.5.1.-) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Epididymis tissue protein Li 189m)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79947
Human Swissprot No.
Q86SQ9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q86SQ9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67422
Mouse Swissprot No.
Q99KU1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99KU1/entry
特异性
This antibody detects endogenous levels of DHDDS at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed at high levels in testis and kidney. Expressed in epididymis (at protein level). Slightly expressed in heart, spleen and thymus.
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein . colocalizes with calnexin.
功能
With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) . Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length . Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol .
