产品名称
Chimaerin 2 Rabbit Polyclonal Antibody
蛋白名称
Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1124
Human Swissprot No.
P52757
Human Swissprot Link
https://www.uniprot.org/uniprot/P52757
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=69993
Mouse Swissprot No.
Q80XD1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80XD1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84031
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q03070/entry
特异性
This antibody detects endogenous levels of Chimaerin 2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas.
细胞定位
Membrane ; Peripheral membrane protein .
功能
GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.
