产品名称
CCDC115 Rabbit Polyclonal Antibody
蛋白名称
Coiled-coil domain-containing protein 115
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84317
Human Swissprot No.
Q96NT0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96NT0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=69668
Mouse Swissprot No.
Q8VE99
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VE99/entry
特异性
This antibody detects endogenous levels of CCDC115 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed throughout the brain.
细胞定位
Endosome . Lysosome . Endoplasmic reticulum-Golgi intermediate compartment . Cytoplasmic vesicle, COPI-coated vesicle . Endoplasmic reticulum .
功能
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation . May be involved in Golgi homeostasis .
