产品名称
C9orf142 Rabbit Polyclonal Antibody
蛋白名称
Uncharacterized protein C9orf142
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=286257
Human Swissprot No.
Q9BUH6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BUH6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=227622
Mouse Swissprot No.
Q8K0Y7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K0Y7/entry
特异性
This antibody detects endogenous levels of C9orf142 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Chromosome . Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation. .; Cytoplasm . (Microbial infection) Upon infection by herpesvirus 1 (HSV-1), it is partially translocated into the cytoplasm in an HSV-1-dependent manner. .
功能
Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination . May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery . Involved in NHEJ by promoting the ligation of blunt-ended DNA ends . Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends . Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair . Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism .
