产品名称
C6orf173 Rabbit Polyclonal Antibody
蛋白名称
Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=387103
Human Swissprot No.
Q5EE01
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5EE01
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66311
Mouse Swissprot No.
Q3URR0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3URR0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=689399
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/A1L1L1/entry
特异性
This antibody detects endogenous levels of C6orf173 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types.
细胞定位
Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . Nucleus matrix . Nucleus, nucleolus . Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis. .
功能
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
