产品名称
C15orf27 Rabbit Polyclonal Antibody
蛋白名称
Transmembrane protein C15orf27
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=123591
Human Swissprot No.
Q2M3C6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q2M3C6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=244886
Mouse Swissprot No.
Q8BZB3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BZB3/entry
特异性
This antibody detects endogenous levels of C15orf27 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Mainly expressed in the cerebellum (PubMed:25165868). Also expressed in cerebral cortex, skeletal muscle and thyroid, but at much lower levels (PubMed:25165868).
细胞定位
Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Perikaryon . Present in the dendrites and soma of cerebellar granule neurons, but not in their axon. .
功能
Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum . Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear . Undergoes both rapid and slow structural rearrangements in response to changes in voltage . Contains a zinc-binding site that can regulate the slow conformational transition .
