产品名称
ESPN Rabbit Polyclonal Antibody
蛋白名称
Espin (Autosomal recessive deafness type 36 protein) (Ectoplasmic specialization protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83715
Human Swissprot No.
B1AK53
Human Swissprot Link
https://www.uniprot.org/uniprot/B1AK53
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56226
Mouse Swissprot No.
Q9ET47
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ET47/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56227
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63618/entry
特异性
This antibody detects endogenous levels of ESPN at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, cytoskeleton . Cell projection, stereocilium . Cell projection, microvillus .
功能
Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells . Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (By similarity). Involved in the elongation of actin in stereocilia . In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation.
