产品名称
PRDM15 Rabbit Polyclonal Antibody
基因名称
PRDM15 C21orf83 ZNF298
蛋白名称
PR domain zinc finger protein 15 (PR domain-containing protein 15) (Zinc finger protein 298)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63977
Human Swissprot No.
P57071
Human Swissprot Link
https://www.uniprot.org/uniprot/P57071
特异性
This antibody detects endogenous levels of PRDM15 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in all tissues examined.
功能
Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming .
