产品名称
PLAG1 Rabbit Polyclonal Antibody
蛋白名称
Zinc finger protein PLAG1 (Pleiomorphic adenoma gene 1 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5324
Human Swissprot No.
Q6DJT9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6DJT9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56711
Mouse Swissprot No.
Q9QYE0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QYE0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=297804
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U2T6/entry
特异性
This antibody detects endogenous levels of PLAG1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 aberrations, with preferential occurrence in benign tumors.
细胞定位
Nucleus . Strong nucleolar localization when sumoylation is inhibited.
功能
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.
