产品名称
RNF219 Rabbit Polyclonal Antibody
蛋白名称
RING finger protein 219
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79596
Human Swissprot No.
Q5W0B1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5W0B1
Mouse Swissprot No.
Q8K2Y0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K2Y0/entry
特异性
This antibody detects endogenous levels of RNF219 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Chromosome . Association to chromatin is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase. .
功能
E3 ubiquitin ligase essential for DNA replication origin activation during S phase . Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase .
