产品名称
BHLHA15 Rabbit Polyclonal Antibody
基因名称
BHLHA15 BHLHB8 MIST1
蛋白名称
Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=168620
Human Swissprot No.
Q7RTS1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q7RTS1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17341
Mouse Swissprot No.
Q9QYC3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QYC3/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25334
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P70562/entry
特异性
This antibody detects endogenous levels of BHLHA15 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in brain, liver, spleen and skeletal muscle.
功能
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
