产品名称
ATAD1 Rabbit Polyclonal Antibody
蛋白名称
ATPase family AAA domain-containing protein 1 (EC 3.6.1.3) (Thorase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84896
Human Swissprot No.
Q8NBU5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NBU5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67979
Mouse Swissprot No.
Q9D5T0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D5T0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=309532
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q505J9/entry
特异性
This antibody detects endogenous levels of ATAD1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Mitochondrion outer membrane ; Single-pass membrane protein . Peroxisome membrane ; Single-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Single-pass membrane protein .
功能
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria . Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).
