产品名称
KIAA0090 Rabbit Polyclonal Antibody
基因名称
EMC1 KIAA0090 PSEC0263
蛋白名称
ER membrane protein complex subunit 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23065
Human Swissprot No.
Q8N766
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8N766
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=230866
Mouse Swissprot No.
Q8C7X2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C7X2/entry
特异性
This antibody detects endogenous levels of KIAA0090 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
功能
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
